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Revotar Gets Positive Phase II Results in COPD

Revotar Biopharmaceuticals achieved positive results in Phase IIa Ozone Study with Bimosiamose for COPD.

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By: Tim Wright

Editor-in-Chief, Contract Pharma

Revotar Biopharmaceuticals achieved positive results in Phase IIa Ozone Study with Bimosiamose for COPD. The study evaluated the effect of Bimosiamose on ozone-induced airway inflammation in healthy subjects with a new controlled breathing nebulizer device. The data supports further development of the new pan selectin antagonist in COPD.

The trial was designed as a double-blind, placebo controlled, randomized cross-over study comprising 18 non-smoking healthy ozone-responsive volunteers. Each subject received nebulized Bimosiamose solution or vehicle for four days twice daily in two subsequent periods separated by a wash-out phase (cross-over). Treatment was followed by ozone challenge and subsequent collection of induced sputum that was analyzed for cellular composition and non-cellular mediators.

Inhalation of Bimosiamose with a new controlled breathing nebulizer device was safe and well tolerated. Compared to placebo, the compound demonstrated a broad and significant anti-inflammatory effect on cellular and non-cellular sputum parameters.

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